Министерство здравоохранения республики казахстан карагандинский государственный медицинский
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- А.А. Турмухамбетова, А.К. Изденов, Д.А. Сагинова, Вистерничан О.А., Ю.Л. Романюк, Литвинов В.И., Койшиман Е., Газизова А.О.
- ISBN 978-601-202-136-3 Ғ96
- The actual problems of modern medicine considered in the compilation, such as such as ecology and human health, problems of clinical medicine and
- Рассчитан на широкий круг научных и педагогических работников, преподавателей, магистрантов, докторантов и студентов.
- N.T. Abatov 1 , M.M. Tusupbekova 1 , J.N. Alberton 2 , Y.M. Assamidanov
- UDC 616.12-008.331.1-08 Abdul Vasim, Shravan Kumar Samota, Mahesh Choudhary, Sunil Choudhary
- Materials and methods.
- UDC 616.12-008.331.1-08 S. Aitbek, S. Zhumashev, O. Buzanov THE EFFECTS OF BIOFEEDBACK FOR THE TREATMENT OF HYPERTENSION
- UDC 616.12-08
- Materialsandmethods
- UDC 616-091.8 Zh. Aknazarova PATHOHISTOLOGICAL CHARACTERISTICS THYROID GLAND WITH ENDEMIC GOITER
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ҚАЗАҚСТАН РЕСПУБЛИКАСЫ ДЕНСАУЛЫҚ САҚТАУ МИНИСТРЛІГІ ҚАРАҒАНДЫ МЕМЛЕКЕТТІК МЕДИЦИНА УНИВЕРСИТЕТІ
МИНИСТЕРСТВО ЗДРАВООХРАНЕНИЯ РЕСПУБЛИКИ КАЗАХСТАН КАРАГАНДИНСКИЙ ГОСУДАРСТВЕННЫЙ МЕДИЦИНСКИЙ УНИВЕРСИТЕТ
THE MINISTRY OF HEALTH CARE OF THE REPUBLIC OF KAZAKHSTAN KARAGANDA STATE MEDICAL UNIVERSITY «Ғылым әлемі және жастар: дамудың бағыты мен жаңа мүмкіндіктері» Жас ғалымдардың халықаралық конференцияның материалдары 12 сәуір 2017 жыл
Материалы международной конференции молодых ученых 12 апреля 2017 года
Materials of international conference of young scientist 12 of April 2017 year
Караганда 2017
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УДК 378 ББК 74.58 Ғ96 Под общей редакцией ректора КГМУ профессора Р.С.Досмагамбетовой
Ғ96 Жинақта қазіргі таңдағы медицинаның өзекті мәселелері, сонымен қатар экология және адам денсаулығы, клиникалық медицина және зертханалық диагностика сұрақтары қарастырылады. В сборнике рассматриваются актуальные проблемы современной медицины, в том числе экология и здоровье человека, вопросы клинической медицины и лабораторной диагностики. The actual problems of modern medicine considered in the compilation, such as such as ecology and human health, problems of clinical medicine and laboratory diagnostics. Рассчитан на широкий круг научных и педагогических работников, преподавателей, магистрантов, докторантов и студентов.
© Карагандинский государственный медицинский университет, 2017 3
N.T. Abatov 1 , M.M. Tusupbekova 1 , J.N. Alberton 2 , Y.M. Assamidanov 1 , A.N. Abatova 1 PATHOMORPHOLOGICAL ANALYSIS OF THE RESULTS OF VARIOUS METHODS NEPHROPEXY 1 Karaganda State Medical University, Karaganda, Kazakhstan 2 Medical Center Shaare Zedek, Jerusalem, Israel
experiment.
the second macroporous partially resorbed light mesh, the third method of nephropexy using its own peritoneum. The nephropexy modeling conducted 96 laboratory rats. Three groups of 32 cases in each: the first group - polyester mesh; second - partially absorbable light mesh UltraPro; third - own peritoneal flap. Terms of breeding animals and histological examinations were carried out within the period of 7, 14, 21 and 30 days. Results: Materials used peritoneal flap and UltraPro are biocompatible and do not generate hyperergic immune response in rat tissue, as not induce persistence and progression alterative and exudative reaction, indicating significant stage-specific reduction in granulocyte and minimum values of plasma cells in the 7, 14, 21 and 30 days (p ≤ 0.05). Conclusions: It was established on the basis of experimental data that the grid and UltraPro own peritoneal flap is characterized by less aggressive fibrosclerotic process compared with a grid of polyester/polyester, in which marked infiltration of lymphocytes and eosinophils, and on day 30 revealed adhesions. When using the peritoneum-fascial flap in the early stages it was also marked lymphoid eosinophilic reaction, although 30 days of the process diminished.
UDC 616.12-008.331.1-08 Abdul Vasim, Shravan Kumar Samota, Mahesh Choudhary, Sunil Choudhary HISTOLOGICAL EFFECT OF OVARIECTOMY AND ESTROGEN REPLACEMENT ON PAROTID GLAND OF ADULT ALBINO RAT Scientific supervisor: M. Zh. Alieva Karaganda state medical university
menopausal and postmenopausal symptoms. Oral discomfort is common among these symptoms.
associated with ovariectomy and to assess the possible beneficial role of estrogen replacement. Materials and methods. Literature reviews. Results. We read a few articles where it was written about replacement on parotid gland of adult albino rat. Mesenchymal stem cells, or MSCs, are multipotent stromal cells that can differentiate into a variety of cell
types, including: osteoblasts (bone cells),chondrocytes (cartilage cells), myocytes (muscle cells) and adipocytes (fat cells). This phenomenon has been documented in specific cells and tissues in living animals and their counterparts growing in tissue culture. Examination of parotid in OVX group showed different forms of degenerative changes. The acini appeared irregular and lined with some apoptotic cells. Their cytoplasm contained extensive vacuolations. Homogenous acidophilic material, cellular infiteration within thick CT septa, dilated ducts with stratification in their lining and congestion of blood vessels were also seen. Positive immunostaining for Cu, Zn-SOD appeared in acinar cytoplasm. Ultrastructurally, rarified dilated RER, electron dence and lucent granules were also seen. Estrogen replacement improved the histological changes in treated group.
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Conclusion.Results obtained in this study suggest that estrogen deficiency in postmenopausal women lead to variable degenerative changes in parotid salivary glands of adult female albino rats with relative limitation of these changes in estrogen supplemented group. We have advanced a lot in our knowledge of the pathology of MS, especially in relation to MS plaques. We are still far from understanding the mechanisms of ongoing deterioration observed in progressive MS.
S. Aitbek, S. Zhumashev, O. Buzanov THE EFFECTS OF BIOFEEDBACK FOR THE TREATMENT OF HYPERTENSION Scientific advisor: Bek Ernur Kasipovich Karaganda state medical university
accepted thresholds in the Kazakhstan at 140/90 mmHg. It is one of the most prevalent and powerful risk factors contributing to the development of cardiovascular disease (CVD) and one of the most important preventable causes of premature morbidity and mortality in developed and developing countries. The estimated lifetime risk of middle-aged men and women developing hypertension is 80–90%. The most common type of hypertension is essential hypertension, which has no known cause.
Biofeedback is defined as a group of non-pharmacological therapeutic procedures that use electronic instruments to measure, process and provide information (feedback) to patients regarding their neuromuscular and autonomic nervous system activity. Patients have been taught these procedures in an attempt to control their blood pressure. If shown to be effective they could be used in the treatment of essential hypertension.
of biofeedback procedures in treating adults with essential hypertension. Other objectives were to model any clinical benefits of biofeedback for the treatment of essential hypertension, provide an overview of currently used biofeedback equipment and offer recommendations for future research. Methods. Two recent systematic reviews with meta-analyses were critically appraised and used as a basis for this updated systematic review, which compares biofeedback procedures with placebo (sham biofeedback treatment), no intervention or other behavioural treatments, as well as with antihypertensive medication. Results. The two existing systematic reviews were judged to be of high quality although there is a question regarding the appropriateness of the pooling of data. Neither review considered any evidence for biofeedback treatment versus antihypertensive medication. The authors of the first review concluded that biofeedback was more effective than no intervention, but was only superior to sham or non-specific interventions when combined with a relaxation technique. The second systematic review indicated that both biofeedback and active control treatments (relaxation training, cognitive therapy and home monitoring) reduced systolic blood pressure (SBP) and diastolic blood pressure (DBP), but only biofeedback significantly reduced SBP and DBP when compared with inactive control treatments (waiting list, blood pressure measured in a clinic, placebo biofeedback controls). The systematic review presented here compared biofeedback treatment with antihypertensive medication, placebo (sham biofeedback treatment), no intervention or another behavioral therapy (including biofeedback) and the primary outcome was effect on blood pressure. A total of 927 non- duplicate references were identified by the search strategy and subsequently screened for inclusion in the review. From these, 41 publications (including three abstracts) reporting 36 RCTs with a total population of 1660 treated patients met the inclusion criteria of the review. In total, 21 trials employed biofeedback treatment with no adjunctive therapy and 15 used biofeedback treatment
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alongside another treatment. The majority of trials were small and had either no post-treatment follow-up or follow-up of less than 6 months.No statistical meta-analysis was carried out as the general quality of reporting of trials was poor and there was a large degree of heterogeneity in terms of treatments and comparators. Outcome measures were inconsistently reported. A narrative summary of the data is presented. Data were grouped first by treatment type and then by comparator. In addition, the type of biofeedback was used to further delineate trials. Author conclusions regarding the efficacy or otherwise of biofeedback treatment versus the comparator were summarized and used as the basis of the analysis. Conclusions. The quality of research in this area is poor. There is currently no evidence that consistently demonstrates the effectiveness of the use of any particular biofeedback treatment in the control of essential hypertension when compared with pharmacotherapy, placebo (sham biofeedback treatment), no intervention or other behavioral therapies. The lack of evidence of clinical effectiveness negated the need to conduct an economic analysis. Given the current standards for the treatment of hypertension, further research is likely to be considered only as an adjunct to pharmacological interventions.
UDC 616.12-08
THE TREATMENT OF ISCHEMIC CARDIAC INJURY WITH MESENCHYMAL STEM CELLS Scientific advisor: Alieva Mausym Zhaksybekovna Department of Histology, KSMU Introduction: Cell therapy for heart failure has the potential to restore cardiac functions by enhancing angiogenesis, regenerating viable myocardium, and protecting myocardium from cell death. Bone marrow stem cells (BMSCs) present an attractive source of cells for the cell therapy.
treatment of cardiac injury. Materialsandmethods: Literature reviews. Resultsanddiscussion: Mesenchymal stem cells, or MSCs, are multipotent stromal cells that can differentiate into a variety of cell types, including: osteoblasts (bone cells),chondrocytes (cartilage cells), myocytes (muscle cells) and adipocytes (fat cells). This phenomenon has been documented in specific cells and tissues in living animals and their counterparts growing in tissue culture. Mesenchymal stem cells are characterized morphologically by a small cell body with a few cell processes that are long and thin. The cell body contains a large, round nucleus with a prominent nucleolus, which is surrounded by finely dispersed chromatin particles, giving the nucleus a clear appearance. The remainder of the cell body contains a small amount of Golgi apparatus, rough endoplasmic reticulum, mitochondria and polyribosomes. The cells, which are long and thin, are widely dispersed and the adjacent extracellular matrix is populated by a few reticular fibrils but is devoid of the other types of collagen fibrils.
These cells are participating in the treatment of cardiac disorders. The mechanisms responsible for the beneficial effects of MSCs on cardiac function that implanted bone marrow-derived MSCs may differentiate into cardiomyocytes and improve cardiac function. Differentiation of MSCs into cardiomyocytes has been demonstrated by culture of MSCs treated with either 5-azacytidine or a cocktail of growth factors. Another hypothesis is that injected MSCs may differentiate into endothelial cells and promote angiogenesis. This event may limit the extension of an infarction area and enhance repair processes of myocardium. Studies demonstrated that transplantation of MSCs enhanced angiogenesis and collateral formation . Implanted MSCs may promote angiogenesis by
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angiogenic factor secretion. MSCs release a major angiogenesis cytokine, vascular endothelial growth factor (VEGF), and can also produce SDF-1, which is critical for recruitment and entrapment of pro-angiogenic myeloid progenitor cells . Cardiac regeneration by MSCs involves release of paracrine factors. The function of these factors is preventing apoptosis of cardiomyocytes, stimulating angiogenesis, helping matrix reorganization, and increasing MSC recruitment . MSCs can secrete a variety of angiogenic, antiapoptotic, and mitogenic factors, such as VEGF, hepatocyte growth factor, adrenomedullin, and insulin-like growth factor 1 . Therefore, the use of paracrine factors secreted from implanted MSCs for infarcted myocardium has the potential to reduce morbidity and mortality associated with cardiac remodeling. An animal study showed that injection of conditioned medium obtained from MSC culture exerted cytoprotective effects on the myocardium . The result suggest that isolation and administration of such factors at high concentrations or engineering MSCs for secretion of larger amounts of such factors can produce more significant protective effects. This strategy of endogenous mobilization has emerged as a viable therapeutic option for ischemic cardiovascular diseases. Patients with heart disease who may not tolerate the invasive procedures necessary for the harvest or transplantation of MSCs may be ideal candidates for this method.
cells participate in regenerating cardiac tissue. Therefore, studies need to be conducted to develop the homing strategies of a sufficient number of stem cells to target organ. The strategies would help to deliver stem cells through intravenous injection, instead of injection into heart. Molecular biological mechanisms for regeneration of injured myocardium after postinfaction have to be studied. Clear understanding on signal pathways to stimulate proliferation of stem cells, homing of cardiomyocytes, and differentiation to cardiomyocyes and endothelial cells would maximize applications of MSCs to regenerate cardiac tissue.
Zh. Aknazarova PATHOHISTOLOGICAL CHARACTERISTICS THYROID GLAND WITH ENDEMIC GOITER Supervisor: Alyieva M. Zh.
The relevance of the topic. Endemic goiter is one of the most widespread forms of pathology, which is observed in many countries of the world. Among non-communicable diseases endemic goiter is one of the first places as the most common manifestation of trace elements and, in particular, iodine deficiency. Iodine deficiency leads to deficiency of the functional activity of the thyroid gland significantly lowers the natural resistance of an organism to infectious and parasitic diseases, and also leads to development of secondary immune deficits. In connection with increasing environmental pollution, this pathology is exacerbated, making its study more relevant. Based on the foregoing, the problem of integrated prevention and treatment of the patients with endemic goiter, becomes very topical. The aim of our study was to study the pathohistological pattern of diffuse toxic and nodular colloid goiters with light and scanning probe microscopy. Method Study of changes in structural properties and the membrane surface of thyrocytesgoitrous tissue of thyroid gland was carried out using light and scanning probe microscopy. By scanning probe microscopy under controlled conditions, a study of the relief and surface properties of thyrocytes, reaching the atomic-molecular resolution. Received drugs 46 biopsy in women with an established diagnosis of diffuse toxic and nodular goiter many of the three periods of ontogenesis: the Mature age I (21-35 years) and II (36-55 years) periods, the elderly (56-74 years).
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Morphological study of the thyroid tissue has some special features [1] and consists of 3 stages. The first stage includes a thorough directions for histological examination. The second stage – macroscopic study. The third stage involves the microscopic description goitrous tissue of thyroid gland [2]. Preparation of histological preparations was carried out in accordance with traditional requirements and preparation stages[3, 4].
Structural-functional unit of the thyroid gland is the follicle, which is located inside the colloid storage of thyroid hormones. Own cells pathologically altered tissue glands surround the colloid in the form of a single layer of secretory follicular epithelium. The microscopic picture of nodular goiters in the polymorphic, but keeps the lobed structure of the gland. However, the slices increased significantly in size. The characteristic morphological signs of diffuse toxic goiter are hyperplastic processes in the thyroid epithelium: papillary proliferation of the epithelium and the neoplastic follicles. Conclusion Thus, the results of histopathological studies by light microscopy established that in diffuse toxic goiter the changes are manifested in the formation of papillary outgrowths into the lumen of the follicle, proliferation extrafollicular epithelium with the formation of pads Sanderson and secondary follicles. An indication of the autoimmune nature of the Genesis of diffuse toxic goiter are revealed lymphocytic infiltrates in the stroma of the gland. Among all types of goiters the incidence of diffuse toxic leader goiter.
Каталог: media -> kgmudoc media -> Ілияс есенберлин kgmudoc -> Министерство здравоохранения и социального развития республики казахстан kgmudoc -> Issn 2305-6045 медицина жəне экология medicine and ecology kgmudoc -> Қазақстан республикасы денсаулық сақтау және әлеуметтік даму министрлігі kgmudoc -> Қмму еңбек (ішкі) тәртібінің kgmudoc -> Министерство здравоохранения республики казахстан kgmudoc -> Қазақстан республикасы денсаулық сақтау және әлеуметтік даму министрлігі kgmudoc -> Министерство здравоохранения республики казахстан kgmudoc -> Қмму ректоры м.ғ. д., профессор Досмағамбетова Раушан Сұлтанқызы kgmudoc -> Қазақстан Республикасы 010000, Астана қ. Бейбітшілік к., 54 үй жүктеу 4.39 Mb. Поделитесь с Вашими друзьями:
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