ҚАЗАҚСТАН РЕСПУБЛИКАСЫ ДЕНСАУЛЫҚ САҚТАУ МИНИСТРЛІГІ
ҚАРАҒАНДЫ МЕМЛЕКЕТТІК МЕДИЦИНА УНИВЕРСИТЕТІ
МИНИСТЕРСТВО ЗДРАВООХРАНЕНИЯ РЕСПУБЛИКИ КАЗАХСТАН
THE MINISTRY OF HEALTH CARE OF THE REPUBLIC OF KAZAKHSTAN
Жас ғалымдардың халықаралық конференцияның материалдары
12 сәуір 2017 жыл
««Мир науки и молодежь: тенденции и новые горизонты»
Материалы международной конференции молодых ученых
12 апреля 2017 года
«The world of science and young people:
tendencies and new horizons
Materials of international conference of young scientist
12 of April 2017 year
А.А. Турмухамбетова, А.К. Изденов, Д.А. Сагинова,
Вистерничан О.А., Ю.Л. Романюк, Литвинов В.И.,
Койшиман Е., Газизова А.О.
қатар экология және адам денсаулығы, клиникалық медицина және зертханалық
диагностика сұрақтары қарастырылады.
В сборнике рассматриваются актуальные проблемы современной
медицины, в том числе экология и здоровье человека, вопросы клинической
медицины и лабораторной диагностики.
Aim: to study the of pathomorphological features in different methods nephropexyin
Methods:The experiment was conducted on adult rats. The first group used polyester mesh,
the second macroporous partially resorbed light mesh, the third method of nephropexy using its own
peritoneum. The nephropexy modeling conducted 96 laboratory rats. Three groups of 32 cases in
each: the first group - polyester mesh; second - partially absorbable light mesh UltraPro; third - own
peritoneal flap. Terms of breeding animals and histological examinations were carried out within the
period of 7, 14, 21 and 30 days.
hyperergic immune response in rat tissue, as not induce persistence and progression alterative and
exudative reaction, indicating significant stage-specific reduction in granulocyte and minimum
values of plasma cells in the 7, 14, 21 and 30 days (p ≤ 0.05).
own peritoneal flap is characterized by less aggressive fibrosclerotic process compared with a grid
of polyester/polyester, in which marked infiltration of lymphocytes and eosinophils, and on day 30
revealed adhesions. When using the peritoneum-fascial flap in the early stages it was also marked
lymphoid eosinophilic reaction, although 30 days of the process diminished.
Abstract. Many women undergo hormone replacement therapy in order to relief the
menopausal and postmenopausal symptoms. Oral discomfort is common among these symptoms.
Aim of work. This work aimed to study the possible histological changes of parotid gland
associated with ovariectomy and to assess the possible beneficial role of estrogen replacement.
adult albino rat. Mesenchymal stem cells, or MSCs, are multipotent stromal cells that
can differentiate into
cells),chondrocytes (cartilage cells), myocytes (muscle cells) and adipocytes (fat cells). This
phenomenon has been documented in specific cells and tissues in living animals and their
counterparts growing in tissue culture.
Examination of parotid in OVX group showed different forms of degenerative changes. The
acini appeared irregular and lined with some apoptotic cells. Their cytoplasm contained extensive
vacuolations. Homogenous acidophilic material, cellular infiteration within thick CT septa, dilated
ducts with stratification in their lining and congestion of blood vessels were also seen. Positive
immunostaining for Cu, Zn-SOD appeared in acinar cytoplasm. Ultrastructurally, rarified dilated
RER, electron dence and lucent granules were also seen. Estrogen replacement improved the
histological changes in treated group.
women lead to variable degenerative changes in parotid salivary glands of adult female albino rats
with relative limitation of these changes in estrogen supplemented group.
We have advanced a lot in our knowledge of the pathology of MS, especially in relation to MS
plaques. We are still far from understanding the mechanisms of ongoing deterioration observed in
Background. Hypertension is defined as persistently high blood pressure, with currently
accepted thresholds in the Kazakhstan at 140/90 mmHg. It is one of the most prevalent and powerful
risk factors contributing to the development of cardiovascular disease (CVD) and one of the most
important preventable causes of premature morbidity and mortality in developed and developing
countries. The estimated lifetime risk of middle-aged men and women developing hypertension is
80–90%. The most common type of hypertension is essential hypertension, which has no known
electronic instruments to measure, process and provide information (feedback) to patients regarding
their neuromuscular and autonomic nervous system activity. Patients have been taught these
procedures in an attempt to control their blood pressure. If shown to be effective they could be used
in the treatment of essential hypertension.
Aim. The primary aim of this report was to assess the evidence for the long-term effectiveness
of biofeedback procedures in treating adults with essential hypertension. Other objectives were to
model any clinical benefits of biofeedback for the treatment of essential hypertension, provide an
overview of currently used biofeedback equipment and offer recommendations for future research.
used as a basis for this updated systematic review, which compares biofeedback procedures with
placebo (sham biofeedback treatment), no intervention or other behavioural treatments, as well as
with antihypertensive medication.
is a question regarding the appropriateness of the pooling of data. Neither review considered any
evidence for biofeedback treatment versus antihypertensive medication. The authors of the first
review concluded that biofeedback was more effective than no intervention, but was only superior to
sham or non-specific interventions when combined with a relaxation technique. The
second systematic review indicated that both biofeedback and active control treatments (relaxation
training, cognitive therapy and home monitoring) reduced systolic blood pressure (SBP) and
diastolic blood pressure (DBP), but only biofeedback significantly reduced SBP and DBP when
compared with inactive control treatments (waiting list, blood pressure measured in a clinic, placebo
The systematic review presented here compared biofeedback treatment with antihypertensive
medication, placebo (sham biofeedback treatment), no intervention or another behavioral therapy
(including biofeedback) and the primary outcome was effect on blood pressure. A total of 927 non-
duplicate references were identified by the search strategy and subsequently screened for inclusion
in the review. From these, 41 publications (including three abstracts) reporting 36 RCTs with a total
population of 1660 treated patients met the inclusion criteria of the review. In total, 21 trials
employed biofeedback treatment with no adjunctive therapy and 15 used biofeedback treatment
follow-up or follow-up of less than 6 months.No statistical meta-analysis was carried out as the
general quality of reporting of trials was poor and there was a large degree of heterogeneity in terms
of treatments and comparators. Outcome measures were inconsistently reported. A narrative
summary of the data is presented. Data were grouped first by treatment type and then by comparator.
In addition, the type of biofeedback was used to further delineate trials. Author conclusions
regarding the efficacy or otherwise of biofeedback treatment versus the comparator were
summarized and used as the basis of the analysis.
consistently demonstrates the effectiveness of the use of any particular biofeedback treatment in the
control of essential hypertension when compared with pharmacotherapy, placebo (sham biofeedback
treatment), no intervention or other behavioral therapies. The lack of evidence of clinical
effectiveness negated the need to conduct an economic analysis. Given the current standards for the
treatment of hypertension, further research is likely to be considered only as an adjunct to
S. Aitbek, S. Zhumashev, O. Buzanov
enhancing angiogenesis, regenerating viable myocardium, and protecting myocardium from cell
death. Bone marrow stem cells (BMSCs) present an attractive source of cells for the cell therapy.
Aim: To discover the role of the mesenchymal stem cells in the treatment of ischemic cardiac injury.
Task: learn and analyze the role and the structural features of the mesenchymal stem cells in the
treatment of cardiac injury.
Mesenchymal stem cells, or MSCs, are multipotent stromal cells that can differentiate into a variety
of cell types, including: osteoblasts (bone cells),chondrocytes (cartilage cells), myocytes (muscle
cells) and adipocytes (fat cells). This phenomenon has been documented in specific cells and tissues
in living animals and their counterparts growing in tissue culture.
Mesenchymal stem cells are characterized morphologically by a small cell body with a few cell
processes that are long and thin. The cell body contains a large, round nucleus with a
prominent nucleolus, which is surrounded by finely dispersed chromatin particles, giving the
nucleus a clear appearance. The remainder of the cell body contains a small amount of Golgi
apparatus, rough endoplasmic reticulum, mitochondria and polyribosomes. The cells, which are long
and thin, are widely dispersed and the adjacent extracellular matrix is populated by a
few reticular fibrils but is devoid of the other types of collagen fibrils.
These cells are participating in the treatment of cardiac disorders. The mechanisms responsible
may differentiate into cardiomyocytes and improve cardiac function. Differentiation of MSCs into
cardiomyocytes has been demonstrated by culture of MSCs treated with either 5-azacytidine or a
cocktail of growth factors. Another hypothesis is that injected MSCs may differentiate into
endothelial cells and promote angiogenesis. This event may limit the extension of an infarction area
and enhance repair processes of myocardium. Studies demonstrated that transplantation of MSCs
enhanced angiogenesis and collateral formation . Implanted MSCs may promote angiogenesis by
growth factor (VEGF), and can also produce SDF-1, which is critical for recruitment and entrapment
of pro-angiogenic myeloid progenitor cells .
Cardiac regeneration by MSCs involves release of paracrine factors. The function of these
factors is preventing apoptosis of cardiomyocytes, stimulating angiogenesis, helping matrix
reorganization, and increasing MSC recruitment . MSCs can secrete a variety of angiogenic,
antiapoptotic, and mitogenic factors, such as VEGF, hepatocyte growth factor, adrenomedullin, and
insulin-like growth factor 1 . Therefore, the use of paracrine factors secreted from implanted MSCs
for infarcted myocardium has the potential to reduce morbidity and mortality associated with cardiac
remodeling. An animal study showed that injection of conditioned medium obtained from MSC
culture exerted cytoprotective effects on the myocardium . The result suggest that isolation and
administration of such factors at high concentrations or engineering MSCs for secretion of larger
amounts of such factors can produce more significant protective effects.
This strategy of endogenous mobilization has emerged as a viable therapeutic option for
ischemic cardiovascular diseases. Patients with heart disease who may not tolerate the invasive
procedures necessary for the harvest or transplantation of MSCs may be ideal candidates for this
Conclusion: Despite injecting a large number of stem cells, extremely small fraction of stem
cells participate in regenerating cardiac tissue. Therefore, studies need to be conducted to develop
the homing strategies of a sufficient number of stem cells to target organ. The strategies would help
to deliver stem cells through intravenous injection, instead of injection into heart. Molecular
biological mechanisms for regeneration of injured myocardium after postinfaction have to be
studied. Clear understanding on signal pathways to stimulate proliferation of stem cells, homing of
cardiomyocytes, and differentiation to cardiomyocyes and endothelial cells would maximize
applications of MSCs to regenerate cardiac tissue.
The relevance of the topic. Endemic goiter is one of the most widespread forms of pathology,
which is observed in many countries of the world. Among non-communicable diseases endemic
goiter is one of the first places as the most common manifestation of trace elements and, in
particular, iodine deficiency. Iodine deficiency leads to deficiency of the functional activity of the
thyroid gland significantly lowers the natural resistance of an organism to infectious and parasitic
diseases, and also leads to development of secondary immune deficits. In connection with increasing
environmental pollution, this pathology is exacerbated, making its study more relevant. Based on the
foregoing, the problem of integrated prevention and treatment of the patients with endemic goiter,
becomes very topical. The aim of our study was to study the pathohistological pattern of diffuse
toxic and nodular colloid goiters with light and scanning probe microscopy.
Study of changes in structural properties and the membrane surface of thyrocytesgoitrous
tissue of thyroid gland was carried out using light and scanning probe microscopy. By scanning
probe microscopy under controlled conditions, a study of the relief and surface properties of
thyrocytes, reaching the atomic-molecular resolution. Received drugs 46 biopsy in women with an
established diagnosis of diffuse toxic and nodular goiter many of the three periods of ontogenesis:
the Mature age I (21-35 years) and II (36-55 years) periods, the elderly (56-74 years).
first stage includes a thorough directions for histological examination. The second stage –
macroscopic study. The third stage involves the microscopic description goitrous tissue of thyroid
gland . Preparation of histological preparations was carried out in accordance with traditional
requirements and preparation stages[3, 4].
Structural-functional unit of the thyroid gland is the follicle, which is located inside the colloid
storage of thyroid hormones. Own cells pathologically altered tissue glands surround the colloid in
the form of a single layer of secretory follicular epithelium. The microscopic picture of nodular
goiters in the polymorphic, but keeps the lobed structure of the gland. However, the slices increased
significantly in size. The characteristic morphological signs of diffuse toxic goiter are hyperplastic
processes in the thyroid epithelium: papillary proliferation of the epithelium and the neoplastic
Thus, the results of histopathological studies by light microscopy established that in diffuse
toxic goiter the changes are manifested in the formation of papillary outgrowths into the lumen of
the follicle, proliferation extrafollicular epithelium with the formation of pads Sanderson and
secondary follicles. An indication of the autoimmune nature of the Genesis of diffuse toxic goiter
are revealed lymphocytic infiltrates in the stroma of the gland. Among all types of goiters the
incidence of diffuse toxic leader goiter.